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KMID : 0438420080150020142
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Korean Journal of Bone Metabolism
2008 Volume.15 No. 2 p.142 ~ p.150
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Dietary Calcium Intake and Bone Metabolism in Korean Postmenopausal Women
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Jang Jeong-Yoon
Kim Sung-Woon
Chung Ho-Yeon
Hwang You-Chul
Jeong In-Kyung
Ahn Kyu-Jeong
Kwon Mi-Kwang
Chon Suk
Oh Seung-Joon
Woo Jeong-Taek
Kim Jin-Woo
Kim Young-Seol
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Abstract
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Objective: There is a consensus that adequate calcium intake helps to prevent bone resorption and osteoporosis
especially in person with low calcium diets. Even though people are concerned about bone health and are encouraged to
take calcium supplementation, we believe that most people do not have enough calcium in their diets. The purpose of this study was to determine the nutritional status, urine calcium, bone markers and their relationship in Korean postmenopausal women.
Subjects: The subjects were 56 healthy female with postmenopausal osteopenia and osteoporosis (mean age, 57.7 years). Dietary calcium, phosphorus and protein were measured by 24 hrs recall method and urine calcium, bone
markers, 25-OH D were measured in the fasting state.
Results: The mean (SD) daily dietary intakes of Ca, P, protein were 616 (211.9) mg, 1002 (258.6) mg, 64.8 (16.7) g
respectively. Only 6.5% of the participants had calcium intake of more than 1000 mg. 55.4% of the subjects showed
25-OH D of less than 30 ng/ml. The subjects showing hypercalciuria were 29.1%. Multiple regression analysis showed
that urinary calcium excretion was associated with serum P, CTX, 25-OH D but not calcium intake. The mean value of
24 hr-urine calcium was 0.22 g and it was significantly decreased into 0.18 g after 6 month supplementation of 500 mg
of elemental calcium and 400 IU of vitamin D. 57.2% of the hypercalciuric subjects showed normocalciuria after supplementation. An average 24 hour-urine calcium excretion decreased among hypercalciuric subjects after
supplementation of calcium and vitamin D. However, an average 24 hour-urine calcium excretion among normocalciuric
subjects did not change after supplementation of calcium and vitamin D. CTX, bone resorption marker was significantly
decreased and spine BMD was significantly increased supplementation for 6 months.
Conclusion: Nutritional support including calcium supplementation should be required for the most postmenopausal women and should be required for the most persons who are interested in improving bone health.
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KEYWORD
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Calcium intake, Calcium excretion, Biochemical markers, BMD
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